From Brooklyn-Queens Expressway: Take Brooklyn-Queens Expressway (I-278) east to Robert F. Kennedy Bridge (formerly the Triboro Bridge). Cross bridge. Follow signs for the Bronx and the Major Deegan Expressway (I-87) north.

From Verrazano-Narrows Bridge: Take Brooklyn-Queens Expressway (I-278) east to Robert F. Kennedy Bridge (formerly the Triboro Bridge). Cross bridge. Follow signs for the Bronx and the Major Deegan Expressway (I-87) north.

From Goethals Bridge: Follow New Jersey Turnpike (I-95) north to the George Washington Bridge. Continue with the New Jersey directions..​

From Throgs Neck or Whitestone Bridge:

Option 1: Follow signs for I-95 south, which becomes the westbound Cross Bronx Expressway. Proceed to Major Deegan Expressway (I-87) south.

Option 2: Follow signs for the westbound Bruckner Expressway (I-278). From Bruckner, take exit for Major Deegan Expressway (I-87) north.

S2.

From New York State Thruway (I-87): I-87 south becomes the Major Deegan Expressway.

From Bronx River Parkway or Hutchinson River Parkway: Take the Cross County Parkway west to I-87 south, which becomes the Major Deegan Expressway.

Option 1: Take eastbound Cross Bronx Expressway (I-95 north). Exit for Major Deegan Expressway (I-87) south.

Option 2: Take eastbound Cross Bronx Expressway (I-95 north). Use Exit 2A (Jerome Avenue). Make right off exit and continue straight on Jerome Avenue to Yankee Stadium.

Option 3: Take Exit 2 (Harlem River Drive). Once on Harlem River Drive south, take Exit 23 toward West 155th Street. At first light after exit, turn left onto West 155th St. Cross Macombs Dam Bridge. Yankee Stadium ahead.

From New England Thruway (I-95): See Long Island Throgs Neck/Whitestone Bridge directions.

From Merritt Parkway: Merritt Parkway becomes Hutchinson River Parkway. Proceed to westbound Cross County Parkway, then to I-87 south, which becomes the Major Deegan Expressway.